A team of Korean researchers recently published the results of a study on histopathologic analysis of myocarditis that occurs after vaccination with Covid-19 vaccines developed by Pfizer and Moderna.
Professor Seo Kyung-jin of the Department of Pathology and Professor Ahn Hyo-suk of the Department of Cardiology at the Catholic University of Korea Uijeongbu St. Mary's Hospital, published their findings in Diagnostics, an internationally renowned journal covering research in the field of diagnostics, titled "Post-COVID-19 Vaccination Myocarditis: A Histopathologic Study on a Monocentric Series of Six Cases".
The paper aimed to assess the extent of inflammation through histopathologic analysis of myocarditis following Covid-19 vaccination. To do so, they identified patients with myocarditis that occurred after Covid-19 vaccination who were hospitalized and underwent tissue biopsy and analyzed the histopathological findings.
The researchers found that many cases of myocarditis were clinically diagnosed but showed only mild inflammation histopathologically.
During the Covid-19 pandemic, vaccination safety has been an important health issue of international concern. In particular, myocarditis after Covid-19 vaccination was a widely recognized vaccine adverse event, and many research papers have been published at home and abroad.
Recently, a study analyzing domestic data at the national level was published. However, very few studies at home and abroad have published histopathologic analyses of myocarditis after Covid-19 vaccination.
"During Covid-19, Uijeongbu St. Mary's Hospital played a big role in northern Gyeonggi Province, treating many patients with coronavirus vaccine-associated myocarditis, which made it possible for us to conduct this study," Professor Seo said.
Professor Ahn said, "We would like to thank all the Uijeongbu St. Mary's Hospital staff for their hard work in treating so many corona-related patients."
Professors Seo and Ahn have researched coronavirus vaccine-associated myocarditis for the past three years in collaboration with Professor Hwang Sung-soon Yonsei University College of Medicine Biomedical Sciences Department. They have published three papers in Frontiers in Immunology, Molecules, Cells, and Scientific Reports on the mechanism of coronavirus vaccine-associated myocarditis using the latest molecular pathology techniques (single-cell RNA).